@article{39681,
author = {Sung Joon Moon and Katherine Cook and Karthikeyan Rajendran and Ioannis Kevrekidis and Jaime Cisternas and Carlo R. Laing},
title = {Coarse-Grained Clustering Dynamics of Heterogeneously Coupled Neurons},
abstract = {
The formation of oscillating phase clusters in a network of identical Hodgkin{\textendash}Huxley neurons is studied, along with their dynamic behavior. The neurons are synaptically coupled in an all-to-all manner, yet the synaptic coupling characteristic time is heterogeneous across the connections. In a network of N neurons where this heterogeneity is characterized by a prescribed random variable, the oscillatory single-cluster state can transition{\textemdash}through N - 1 (possibly perturbed) period-doubling and subsequent bifurcations{\textemdash}to a variety of multiple-cluster states. The clustering dynamic behavior is computationally studied both at the detailed and the coarse-grained levels, and a numerical approach that can enable studying the coarse-grained dynamics in a network of arbitrarily large size is suggested. Among a number of cluster states formed, double clusters, composed of nearly equal sub-network sizes are seen to be stable; interestingly, the heterogeneity parameter in each of the double-cluster components tends to be consistent with the random variable over the entire network: Given a double-cluster state, permuting the dynamical variables of the neurons can lead to a combinatorially large number of different, yet similar {\textquotedblleft}fine{\textquotedblright} states that appear practically identical at the coarse-grained level. For weak heterogeneity we find that correlations rapidly develop, within each cluster, between the neuron{\textquoteright}s {\textquotedblleft}identity{\textquotedblright} (its own value of the heterogeneity parameter) and its dynamical state. For single- and double-cluster states we demonstrate an effective coarse-graining approach that uses the Polynomial Chaos expansion to succinctly describe the dynamics by these quickly established {\textquotedblleft}identity-state{\textquotedblright} correlations. This coarse-graining approach is utilized, within the equation-free framework, to perform efficient computations of the neuron ensemble dynamics.
},
year = {2015},
journal = {Journal of Mathematical Neuroscience},
volume = {5},
pages = {2},
url = {http://www.mathematical-neuroscience.com/content/5/1/2},
doi = {10.1186/2190-8567-5-2},
language = {eng},
}